1542
Culture
Juan Rodríguez Cabrillo becomes first European to reach San Diego Bay
1769
Culture
Father Serra founds Mission San Diego de Alcalá
1821
Government
Mexico gains independence; San Diego becomes Mexican territory
1846
Politics
Battle of San Pasqual during Mexican-American War
1850
Government
San Diego incorporated as one of California's first cities
1885
Transport
Transcontinental railroad reaches San Diego
1906
Government
U.S. Navy establishes first permanent presence in San Diego
1915
Culture
Panama-California Exposition opens in Balboa Park
1927
Science
Spirit of St. Louis built by Ryan Airlines in San Diego
1935
Culture
California Pacific International Exposition in Balboa Park
1942
Government
San Diego becomes Pacific Fleet headquarters for WWII
1960
Culture
UC San Diego founded
1969
Science
UCSD becomes one of first ARPANET nodes
1978
Disaster
PSA Flight 182 crash kills 144 in North Park
1985
Sports
San Diego Padres reach first World Series
1988
Transport
San Diego Trolley expands to border crossing
1998
Business
Qualcomm drives tech boom in San Diego
2003
Disaster
Cedar Fire becomes largest wildfire in California history
2007
Disaster
Witch Creek Fire destroys 1,600 homes
2016
Sports
Chargers announce move to Los Angeles
2020
Science
San Diego biotech sector leads COVID-19 response efforts