1758Government
In 1758 a settlement was established at this site by Shawnee Indians who had abandoned their village of Lower Shawneetown in November of that year.
1795History
After the Treaty of Greenville in 1795 forced the Native Americans from most of Ohio, European settlers came to the area.
1796Government
The community Chillicothe was founded in 1796 by a party led by General Nathaniel Massie on his land grant.
1798Government
In 1798, Ross County became incorporated with Chillicothe as the county seat.
1800Government
Chillicothe was named the capital of the remnant Northwest Territory in 1800, when Indiana Territory was split off, and the Northwest Territory was reduced to Ohio, eastern Mich...
1802Military
In 1802 as Ohio moved toward statehood, the city hosted the Ohio Constitutional Convention.
1803Government
It served as the capital of Ohio from statehood in 1803 until 1810 then again from 1812 to 1816.
1853Architecture
In 1853 the Masonic Hall was built, as the first incarnation of what is now the Majestic Theatre.
1876Architecture
In 1876 the Masons appointed a building committee to enlarge their building.
1914History
The Masonic Opera House continued under Wolf's managerial abilities until he sold it to the Myers Brothers in 1914.
1946Government
Ohio University – Chillicothe is a regional campus of Ohio University founded in 1946.
1948History
On May 12, 1948, a C.
1954Architecture
Memorial Stadium, which opened in 1954.
1971Culture
In July 1971, Harley and Evelyn Bennett became the new owners of the Majestic Theatre.
1974Government
Chillicothe is home to Pickaway-Ross Career & Technology Center, a vocational-technical school founded in 1974.
1984Culture
Started in 1984, the May festival draws crowds of approximately 85,000.
1990Culture
Three Chillicothe businessmen (Robert Evans, Robert Althoff and David Uhrig) bought the theater as a non-profit organization in 1990.
1993Government
== Sports ==
The Chillicothe Paints are a baseball team that was established in February 1993.
2007Education
Ross County Christian Academy was formed in 2007 and now offers K through 12th grade at two sites.
2008Sports
The team was previously a member of the Frontier League, playing there from its founding until 2008.
2010History
=== 2010 census ===
As of the census of 2010, there were 21,901 people, 9,420 households, and 5,559 families residing in the city.
2025Economy
In April 2025, the Pixelle paper mill, formerly named for past owners Glatfelter and Mead Paper, and employing about 800 people, announced its closure.