1775History
Nogales was at the beginning of the 1775–1776 Juan Bautista de Anza Expedition as it entered the present-day U.S.
1841Government
In 1841, a land grant from the Mexican government to the Elías family established Los Nogales de Elías.
1853Culture
Following the Gadsden Purchase in 1853, Nogales became a part of the United States of America.
1880History
In 1880, Russian-Jewish immigrants Isaac and Jacob Isaacson homesteaded the trading post of Isaacson, Arizona, at present-day Nogales.
1883Architecture
Postal Service opened the Isaacson post office but renamed it as Nogales in 1883.
1904History
On the second floor of the 1904 Nogales Courthouse is a small room dedicated to the 1775–1776 Anza Expedition.
1915History
In 1915, according to historian David Leighton, Sonora Gov.
1918Military
On August 27, 1918, a battle between United States Army forces and Mexican militia – mostly civilian in composition – took place.
1978History
The lowest recorded temperature was −4 °F (−20 °C) on December 8, 1978.
1990History
At the Nogales 6 N station, the all-time highest recorded temperature was 112 °F (44 °C), which was reached on June 26, 1990.
2001Military
Oscar winner Benicio del Toro dedicated his award to Ambos Nogales during his acceptance speech at the 73rd Annual Academy Awards in 2001.
2010History
== Demographics ==
As of the 2010 census, there were 20,878 people, 5,985 households, and 4,937 families residing in the city.
2013Culture
The Hangover Part III (2013) was partially filmed in Nogales during late 2012.
2022Culture
Dog (2022) was partially set in Nogales, as the location for the funeral scene at the end, although these scenes were filmed in Los Angeles, California.