1892History
That great corporation decided upon this site as a permanent location for its shops and auxiliary establishments, and on May 17, 1892, ground was broken.
1893Military
The great shops, covering about six acres, were first opened on April 1, 1893, with forty employees.
1894Government
The village is named for Chauncey Depew, a politician and one of the original investors who bought the land for the village, which was incorporated in 1894.
1895Architecture
The brass works were burned May 23, 1895, but immediately rebuilt.
1896History
A Roman Catholic church and an independent Polish Catholic church were erected in 1896.
1897Architecture
The Depew Terminal Railroad was built from Depew to Blasdell in 1897.
1904History
In 1904, Quebec political figure William Clendinneng died in Depew after being hit by a train.
1919Education
Depew High School has a long-standing rivalry, starting in 1919, with Lancaster High School.
1934Culture
Federally commissioned murals were produced from 1934 to 1943 in the United States through the Section of Painting and Sculpture, later called the Section of Fine Arts, of the T...
1941History
== Historic places ==
The United States Post Office contains a mural, Beginning of the Day, painted in 1941 by Anne Poor and was listed on the National Register of Historic Plac...
2010History
== Demographics ==
As of the census of 2010, there were 15,303 people, 6,832 households, and 4,625 families residing in the village.
2017History
Village residents voted on January 17, 2017, to not dissolve the Village of Depew into the Towns of Lancaster and Cheektowaga, by a margin of 3,006–1,165.